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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

奥巴马将迎来第二个任期,摆在他面前的任务依然很艰巨:如何处理1万亿美元的高额年度财政赤字,如何削减高达16万亿美元的国债,如何改革开支高昂的社会事业,如何应对党派斗争激烈陷入僵局的美国国会等等。
但并非所有记者──比如笔者本人──都认同这个最终评估结果。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Based on the children's books that goes by the same name, this movie follows the adventures of Mowgli through the Jungle as he tries to discover himself. He comes across several creatures in the Jungle, played by various actors, who make his journey difficult.
The questions New Yorkers ask the column are dictated not only by their individual circumstances but also by the larger issues of the day, like rising housing costs, gentrification and shoddy construction. In the end, 2014 was a year of things going up — home prices, rents and, above all, buildings, with 16,700 units approved for construction through October, according to the Real Estate Board of New York.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 重庆房地产整治加入“司法手段”
Open Access Perspective

Soft matter science and the COVID-19 pandemic

2016年,高管薪酬均值达709万元,同比增长8%,跑赢了我国国内生产总值6.7%和人均可支配收入6.3%的增速。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

去年2月份中国国家旅游局启用一个名为“美丽中国”的标志,意在向海外宣传推广其旅游形象,然而有人讽刺“美丽中国”这一名称与中国城市在严重污染之下那一张张“不太美丽”的照片相比反差太大。希望专家们今后能设计出一个好一点的方案来。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

vt. 买,购买
The official Facebook page for students admitted to join the Harvard Class of 2021 warns students that "Harvard College reserves the right to withdraw an offer of admission under various conditions including if an admitted student engages in behavior that brings into question his or her honesty, maturity, or moral character".
11月份,财新赞助的中国综合PMI指数读数为50.5。这是自7月份以来,该指数首次超过50这个区分收缩和扩张的荣枯线。
[sju:'pri:m]

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 家居体验馆引领家装新潮流
Perspective

Trends and targets in antiviral phototherapy

节目40 歌曲《难忘今宵》李谷一 张英席 白丽莎(孔子学院学员)、茹丝(孔子学院学员)、李天翼(孔子学院学员)、吴孟天(在华留学生)
Comic skit “I Want To Be In Spring Festival Gala” (Various artistes)
8.请时刻注意证明你不是恐怖分子,这样就是对奥运组委会和主办方最大的帮助。别没事冒冷汗,别随便脱鞋子,别一边发短信一边诡异的微笑,别指着某处大喊:“嘿!看导弹部署在那边屋顶上!” 事实上,如果你的手闲着没事儿,最好能放在让所有人都能看见的地方。
不过无需置疑,软件的收购同时意味着“人才的收购”,雅虎买下的不只是产品,还有产品背后的人。达洛伊西奥如今已是雅虎伦敦分部的全职员工,而他的青春活力以及无可厚非的独特潜质给这个曾经腐朽老旧的科技巨头注入了迫切需要的新鲜活力。雅虎CEO玛丽莎?梅耶尔赞赏他“力求设计的完美和产品的简约”,并称自己“被他的创造活力和坚韧精神所感染”。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

此外,该报告还指出,雨果博斯、雪佛兰和舒洁则跌出了该榜单。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

同时,11月服务业PMI指数是51.2。此前的10月份该指数为52。本周早些时候报出的11月份制造业PMI指数为48.6,高于48.3的预期。10月份该指数则为48.3。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

New Year’s greetings and best wishes!致新年贺忱与最美好的祝福!
New Year's greetings and best wishes!

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Sport dominated the trending searches, with Euro 2012 and Olympic tickets showing the biggest rises in interest ahead of Houston and the Duchess of Cambridge.
榜单前十位富豪的净资产总额合计为5054亿美元。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

A recent example: When Gwen Stefani launched her new album Spark the Fire, Swyft created a free sticker pack and distributed it on several of its messaging apps. It was downloaded almost a million times and sent between users seven million times, resulting in 41 million impressions in 10 days. Such campaigns cost anywhere from $50,000 to $250,000 for brands, Wray says.
奇才队如果想要留在强队之列,需要尽快给球队动手术。我们已经看到了他们一直以来期待的全员奇才是怎样的水准。

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 西城在房山等四区设学区
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

'She enjoys it and we don't force her to do anything she doesn't want to do.'
Snap, however, has sunk to about $15 after initially rallying from its IPO price of $17 in March, damping some expectation of further activity involving so-called decacorns, tech companies that have achieved valuations of $10bn or more through private funding.
7. Viceroy's House
单词severe 联想记忆:

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

10.Be Dedicated and balanced

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

2015年,全球范围发起的233起反倾销案件中,针对金属行业的案件占比达创纪录的46%,几乎全部是针对钢铁行业的案件。
作为宝莱坞片酬最高的女演员之一,迪皮卡·帕度柯妮是2015全球十大美女榜的季军。在印度,她是性感女神、时尚偶像。帕度柯妮在印度各类魅力女性榜上的排名都很靠前。完美的身材、深邃的眼神和迷人的微笑使她脱颖而出。她是许多品牌的代言人,包括天梭、索尼数码相机、雀巢咖啡、沃格眼镜、美宝莲和百事可乐等等。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

而最终取得压倒性胜利的是福特公司(Ford)的CEO马克?菲尔茨(Mark Fields),去年年初他曾令人沮丧地宣布他的公司正“从一家汽车公司向一家汽车公司兼出行公司转型”。他紧接着声称:“遗产是蕴藏着前景的历史。”他超爱这句话,说了不止一次。这句话被他翻来覆去地说,让我觉得它不像格言反倒更像废话。因此本年度新晋“首席蒙人冠军”(Chief Obfuscation Champion)非菲尔茨先生莫属。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 王府井步行街将延长
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

In fact, create a hard and fast rule to keep work and job searching separate. That means no sneaking out for a phone interview. No browsing job boards. No applying or networking with your work email address. "You don't watch porn at work, and you don't work on your résumé at work," Kay says. "You just don't."

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

Another positive of the scheme is that it encourages professional flexibility, preparing the young for the career zigging and zagging that might be necessary in the modern world of work.
根据欧洲央行的最新预测,迄今难以实现像美国或英国那样强劲增长的欧元区,2016年将增长1.7%。今年欧元区将实现1.5%的增长,得益于量化宽松支持经济。
还有哪对系列电影的荧幕情侣可以像《暮光之城》的克里斯汀?斯图尔特和罗伯特?帕丁森这样成功开创戏路呢?两个人都成为了影坛名角。帕丁森在最新作品《好时光》中延续了他近年来这种让人几乎认不出的造型风格。在《迷失Z城》中,他把自己打扮成胡子蓬乱的眼镜男,如今他又把头发染成亚麻色,变身为一个试图在纽约完美做案,结果却让患有发育性残疾的弟弟(本?萨弗迪饰)被捕的银行抢劫犯。他试图用盗取的钱来给弟弟交保释金,结果麻烦接踵而至。很多的麻烦。除了饰演弟弟一角外,本?萨弗迪还和自己的哥哥约书亚?萨弗迪共同执导了这部电影。《好时光》入围了今年戛纳电影节的主竞赛单元,参与角逐金棕榈奖。该片于11月3日在日本上映,11月17日在英国和爱尔兰上映,11月23日在希腊上映。(资料来源:A24制片公司)
Summly attempts to solve this problem by creating “snapshots” of stories that allow readers to browse more quickly than reading full articles. The app will close down but Mr D’Aloisio’s technology will be integrated into Yahoo’s mobile apps.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

charity
“I thought it would be impossible to replace Steve, and to some extent that’s true,” says Professor Michael Cusumano of MIT’s Sloan School of Management. “But internally the spirit is still alive and the company is organising around a less confrontational culture. We have to give Tim credit for that.”
established
adj. 最高的,至上的,极度的
adj. 易坏的,脆弱的,浅薄的 n. 复写纸,薄纸副本

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

9.Touchscreens
The show is iconic among those who grew up in the 1990s because it explores core themes like friendship, struggling to survive in a big city, and finding independence and identity, all of which are still relevant to young audiences today.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

自2004年抵达土星以来,卡西尼号宇宙飞船已经将土星、土星环及土星卫星的图片传送回地球。卡西尼号于9月完成使命,按计划撞向土星大气层中焚毁。卡西尼号在研究土星的同时,还探索了可能存在外星生命的土卫六和土卫二。它使人们更加深入地了解了太阳系,这种影响还将持续,科学家将继续对它收集的数据进行分析。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

我们只把精力在应该关注的地方

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

当伊利诺伊大学的研究员着手建立一种靠嗅觉来鉴别化学物质的装置时,他们并不满足于提高人类鼻子的灵敏度。相反,他们发展出一种假鼻子,依靠对细菌的气味来鉴别和诊断某些疾病。
STEP 5: GET RID of most of your friends
其实,在第一部iPhone手机发布的前一年,LG集团已经推出了全触屏手机。虽然那也不是第一台触屏手机。1992年,世界上第一台触屏手机IBM Simon发布。而触屏技术在"西蒙"之前已经出现。1965年,E·A·约翰逊发明了第一个触屏设备——平板电脑,截止到1995年,一直由空中交通管制员使用。本特·斯顿普和弗兰克·贝克(Frank Beck)在20世纪70年代早期发明了电容式触屏,与约翰逊所发明触屏不同的是,它不能用手指操作,而是需要使用触控笔。在1971年,山姆·赫斯特发明了第一台电阻式触屏,他称之为"电子图表"。手指和触控笔都可以对它进行操作。在1985年,惠普公司发明了世界上第一台触屏电脑H-P150。在1993年,苹果公司也发布了第一个触屏设备——牛顿个人电子助理设备。但此产品并不成功,它的销量很低。
2.你突然变成Twitter上面思想领军人物。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Kay说我很一直很吃惊因为很多人都会告诉他们的同事找工作的事。这是你做的最糟糕的事情之一。理论上说你不能告诉任何同事,但是有时你不得不告诉他们因为想得到他们的引荐。如果那样的话Kay说,你得挑一些值得信任的人,他们不会背后秘密异议也不会口误说出去。
你可以在任何时候进行冥想,但你可以在学习之前的15分钟,上课前的15分钟,考试前的15分钟进行冥想,你就会自己身为学生的良好表现而感到惊讶了。
在英国,从2004年到2014年,非本土出生的人口增长了66%。最近的全民公投中,投票选择“离开”的人大都说移民问题是自己最大的顾虑。
Sectors: what’s in

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

债券大王比尔?格罗斯(Bill Gross)承认:“QE必须结束。”数万亿的低成本资金“扭曲了激励机制,将资产价格推高至人为水平”。但现在格罗斯说“美联储的计划可能过于仓促了”。
Frustrated, he invented something that would allow him take a picture of himself: He called it the "extender stick." Since the iPhone really hadn't been invented yet, a small camera was to be attached to one end of the stick. It also had a small mirror in its front so that users could see how they would look in the photograph. He patented the "extender stick" in 1983. The product was mass produced for sale but it was a commercial failure. The quality of the pictures was low. Besides, previous research showed that the women back then were embarrassed by the idea of taking pictures of themselves. The selfie stick was then reinvented by Wayne Fromm in the year 2000, three years before Hiroshi's patent expired. Fromm called his the "quik pod." He believes he is the inventor of today's selfie sticks and has even sued several other selfie stick producers. When asked about Hiroshi's selfie sticks, he said they were "prior art."

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Baoneng’s raid has been bitterly resisted by Wang Shi, Vanke’s founder who has sought out white knights in a so far successful effort to retain control of the management-led company. The takeover battle fuelled a surge both in the price of Vanke’s Shenzhen-traded shares and Mr Yao’s known worth.
美国国家篮球协会(NBA)近日宣布,NBA全球赛将在中国举办两场金州勇士队对明尼苏达森林狼队的季前赛。
n. 块,大量,众多
So what forces will shape the questions asked next year? It depends on who (and where) you are. While buyers should brace for another year of high-stakes bidding wars, residents of the city’s far-flung neighborhoods (I’m talking about you, Grand Concourse) should be ready for an onslaught of prospective residents seeking bargains — bargains, that is, relative to the gilded ZIP codes that are out of the reach of most mortals.
你可能从未想过一根皮带可以与人工智能相结合,但Belty做到了,并使它看起来很时尚。这个belty会让你不自觉就觉得,“为什么我需要这个?”然后你想可能会是,“如果是黑客入侵,他们把它系得很紧我不能呼吸该怎么办?”第一个问题是合理的;第二个问题有些牵强,但如果它让你三思而后买这个产品,这并不是一件坏事。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

税:2014年约为16866美元(约合人民币10.8万元)
北京某投资公司总经理汪杰表示,金融和地产业高管较高的薪酬反映出我国发展不平衡的问题。
['rep?twɑ:]

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Unlicensed drivers who engage in the services will face a fine ranging from 10 thousand yuan ($1,500) to 30 thousand yuan ($4,500).
But some people might just remember the mustaches.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

Like any college kid, Evan Wray loved using the tiny pictograms known as emoji. But he hated that there was no emoji to express his Fighting Irish pride with fellow University of Notre Dame students. So, alongside co-founder Sean O’Brien, he built a modest business on that disconnect. TextPride, as it was called, licensed images from brands in the sports and entertainment world and sold them as sticker packs. Within a messaging app like Kik, users could buy a packet of stickers for Disney’s Frozen for $1.99, for example.
尤吉利时机恰当和思虑周密的举动应该能扭转猛龙下滑的颓势。
2. Staying too long in a job that you want to leave

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

v
以下是CareerCast公布的完整榜单:
The surviving cat, since named Trooper, has recovered and found a new home.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Total net profit for China’s commercial banks grew by 2.4 per cent last year, according to data from China’s bank regulator. Smaller banks saw increases in profit growth, while bigger banks slowed down.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

Some people remain attached to a theory that can be described as resource scarcity. At its heart this theory suggests that resource development follows a linear pattern in which low-cost resources are developed first, meaning that most if not all future development must be more costly. Unfortunately the history of the industry does not support this view. If anything the experience of the past few decades suggests that the opposite is true.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Sun said he tried to pry open the elevator door, but dismissed the idea and instead leaned against the wall concerned there could be a malfunction that would send the elevator in a free fall.
Sun said he tried to pry open the elevator door, but dismissed the idea and instead leaned against the wall concerned there could be a malfunction that would send the elevator in a free fall.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

[k?n'vi:nj?nt]
According to a 2014 survey it conducted, 86 per cent of respondents who finished the two years said they were taking action to end educational in-equality through their work and 65 per cent outside of their work.
Her piece, titled “Back to Mother Nature," depicts an elaborate water-cleaning machine. Zhang worked with a team of artists at Google to animate her drawing.
The film screens in China reached 41,179 as of the end of 2016 with another 1,612 cinemas and 9,552 film screens built during the year, according to a report by People's Daily.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

对于韩国部署萨德的决定,中国政府已经以越来越大的愤怒加以回应。尽管韩国坚称该系统旨在保护韩国免受朝鲜导弹的打击,中国却担心该技术会令这个美国的盟国查探中国的军事动向。
The companies that have tried — and so far failed — to create a sustained ETF boom in Asia say the need for wholesale reform suggests the market will be defined by a protracted effort to convince both the regulators and customers to redraw the scenery.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Without a cellphone at hand, Sun tried yelling to get the attention of people outside, but no one responded as time passed by.
7.Finding Dory

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

We will deepen rural reform.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

下面是我对2010年美国经济以及市场前景最乐观也是最终的猜测。
中国进口下降在很大程度上源于大宗商品价格走低,而后者反过来又是中国总体需求下降的结果。中国已经多年是铁矿石、煤炭、铜等材料的世界最大消费国。
8)让我想想:是的,这话听起来有点像托词。有时,它就是托词。事实是,我们不可能任何时候都有权或有资格做决策。这句话为你赢得了思考的时间,你大可喘口气。然后,设定好日期及具体时间,做好跟进工作,让对方知道你很在乎他。
《生活大爆炸》中绝不缺少天才。不只是因为这部剧向观众展示了很多绝顶聪明的科学家,同时,演员玛伊姆·比亚利克还拥有神经学博士学位。因此,演员们想要在剧中展示他们的聪明才智,并将整部剧做到精益求精,这也不足为奇。剧中谢尔顿和莱纳德的公寓里有一块很大的白板,这对铁哥们几乎在处理任何事时都会用到它,从完成从学校带回来的工作,到决定是否等到看完最新一部《蜘蛛侠》再吃饭,都离不开这块白板。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
From the themed collection: 浙江省出台办法规范“网约房”
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

2013年日圆兑美元下跌21%,这为日本吸引来1,000万海外游客,尽管中日两国在东中国海(中国称东海)存在领土争端,然而这些游客中有许多是来自中国的富人。
威尼斯被普遍认为是世界上最浪漫的城市之一,也是许多游客必来的水上城市。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

"The articles were submitted with reviewer suggestions, which had real researcher names but fabricated email addresses," Peter Butler, editorial director for cell biology and biochemistry at Springer Nature, told Shanghai-based news website The Paper.
"password" had held the top spot in the rankings since the annual list began to be compiled. In 2013 it slipped to number two on the list.
该数据突显出,某些工业部门对他们认为来自中国对手的不公平竞争感到日益担忧。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

印度梅加拉亚邦——《孤独星球》上说:“梅加拉亚邦这种平静的状态不会维持太久的,在寻求刺激的人群占领卡西山之前赶紧去那里吧!”照片上拍摄的是乞拉朋齐瀑布,它是印度最高的飞瀑,高达340米。
So what forces will shape the questions asked next year? It depends on who (and where) you are. While buyers should brace for another year of high-stakes bidding wars, residents of the city’s far-flung neighborhoods (I’m talking about you, Grand Concourse) should be ready for an onslaught of prospective residents seeking bargains — bargains, that is, relative to the gilded ZIP codes that are out of the reach of most mortals.
The report noted that 201 million people or 27 percent of Internet users were from rural areas, or a gap of 45.2 percent in the Internet penetration rate between urban and rural areas.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

2、冷静自若。007总是很平静。(对男女来说都有用)。即便是在死到临头的时候,也很冷静。这就是性感啊。邦德从不慌张失措。你没见过邦德腿发软手发抖吧。他讲话时语速慢而谨慎,从不乱阵脚。这些都是极富魅力的品质,遭遇劲敌面不改色-这很容易让女人心动不已。他从不向女人表白个不停,就让她们猜不透,搞不懂,这样更加有吸引力。邦德不常微笑也为他的性感加分,因为有幸福感的男人吸引不了女人。007的肢体语言很强势,阳刚血性,从不畏惧;007从不喋喋不休,让他更加优雅;007从不懒散,挺拔的体姿不仅增加自信心,还有力量感,看起来更强壮(身着燕尾服与恶棍搏斗看起来更有档次)。
Length of program: 22 months

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
From the themed collection: 内房股、内银股在香港集体下挫
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

对于网瘾的焦虑导致了一个定位模糊的新行业的出现:网癖训练营,由退伍军人管理,承诺帮助青少年戒除网瘾。但是 由新京报与镜报在近日发表的调査报告中显示,在郑州林伯强新思路生活训练学校(该学校声称自己是河南省东部的一个网瘾康复营)中存在虐待的情况,至少一名学生死亡。
The number of Web users grew by 42.99 million in 2016, or 6.2 percent from the previous year, accounting for 53.2 percent of China's total population, the report said.
《不安感》

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

大部分的科技从业人员都认为移动应用会发展、而电脑应用会减弱。这意味着企业都需要强劲、快捷和实用的移动平台,不重视这点的企业必然会失去消费者。
鲜菜价格同比上涨13%,助推食品价格同比上涨3.7%,涨幅比上月扩大0.5个百分点。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

在NBA,很少人能防得住罗斯。那么,你可以想象,在罗斯的高中年代,有着和现在一样的NBA身板,要防住他更是天方夜谭。
我国近日发行的2016年猴票同样由黄永玉创作。面值为每张1.2元钱,也颇受关注。在正式发布之前,收集者已经在邮局外排起了长队。
国家大学排行榜单数量从去年的38份上升到42份。新加入的榜单包括阿根廷、墨西哥、巴基斯坦和罗马尼亚大学排行榜。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Age: 50

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

排球拳击乒乓球举重沙滩排球铁人三项艺术体操蹦床篮球射击羽毛球艺术体操足球网球
凯特哈德森接受ELLE专访谈感情

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
From the themed collection: 2016家居行业必须关注的四件大事
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

v. 劳累,拉紧,过份
她声名在外,母亲不得不为她雇了专人保镖团队,全天24小时保护她的安全。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

'Short Term 12' is one of those small indie features that stays with you in a big way. It's only 96 minutes long, a modest production set in a foster-care facility for troubled teens. Yet Destin Cretton's direction and Brie Larson's performance elevate the film to, well, one of the year's very best. Ms. Larson is almost a sure thing for not getting an Oscar-this year's competition is unusually fierce-but do catch up with her portrayal of Grace, a 20-something supervisor who is far from untroubled in her own life.
但行业观察人士说,这样的观点忽略了一个中国在创新方面与西方竞争对手直接对峙的领域:让中国版本更具互动性、使用起来也更有趣的那些额外功能。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

排在榜单第三位的是31岁的克丽茜·泰根,她在过去的12个月里赚得1350万美金,首次跻身榜单。
It Pays to Get Along

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

怎样写简历?

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

9. “Creed”(Ryan Coogler)
The biggest falls in brand values include oil and gas companies, still suffering from low commodity prices, and banks, which face growing competition from rival payment systems such as PayPal — whose brand value increased by 35 per cent (see story page 2).
艾瑞咨询集团和中国最火的微博平台——新浪微博在上海的一个论坛上发布了该报道。该论坛由微博和通信巨头华为联合举办。
两岸是骨肉同胞,血浓于水,不管岛内形势如何变化,都割断不了两岸的亲情,也改变不了我们维护两岸关系和平发展的决心和诚意。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

8.出租车司机

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

联合国世界知识产权组织(WIPO)、英士国际商学院和美国康奈尔大学联合发布的年度报告显示,全球第二大经济体正在赶追创新领域那些传统的领先者。目前,第一集团主要是由瑞士、瑞典、英国和美国引领。
[.reidi'ein]
“他随和、真诚、亲切,”IBM首席执行官罗睿兰(Ginni Rometty)说,并赞赏他“非常本真。这是现代CEO的特质。所见即所得。”

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Ah yes, the other reason Sacramento shouldn't tank: Philadelphia has the option to swap picks with them this year. It's actually impossible for the Kings to get the No. 1 pick because of that, and it hurts their chances at a top-three pick overall.
去年,中国工商银行的每股盈利为0.77元人民币,低于上一年的0.78元人民币,税前每股分红为0.2333元人民币,低于上一年的0.2554元人民币。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

你一直感到压力很大
Science and engineering fields dominate the list of highest-paying college majors, with software engineering, bioscience, and electronic information engineering among the most lucrative majors.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

Other high points for the school include being first for alumni international mobility, second for international experience and third for job placement.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 商家进建材市场 要交质量保证金
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

冲击奖项:很难相信斯特里普得不到最佳女主角提名,而汉克斯在销声匿迹几年后,早该获得一项表演类提名了。
“It’s fundamentally about ‘who are we?’” said Eric Kaufmann, a professor of politics at Birkbeck College, University of London. “What does it mean to be part of this nation? Is it not ‘our’ nation anymore, ‘our’ meaning the ethnic majority?
尽管曾在8月份做出让人民币贬值的不了了之的尝试(此举震撼了全球市场,很快就被北京方面放弃),但9月份中国的贸易加权汇率同比上升8.5%,这意味着中国出口产品的竞争力有所减弱。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
From the themed collection: 二线城市是2016年楼市主攻阵营
Paper

Length-scale dependence of protein hydration-shell density

然而,她辩称,亚洲ETF流动性较低的问题反映了基金分销体系未能激励中介销售ETF。她说:“我认为没有快速的解决办法,但如果亚洲转向收费模式,会出现起色。”
泡沫气球是泡泡和气球的混合体。
The number of people holding degrees from colleges or universities reached 170.93m, which means there were 12,445 people with an advanced education per 100,000 people in 2015, up from 8,930 in 2010. The number of people who had attended a senior high school also increased, and the number who had only completed lower-level education fell.
The special tokens of appreciation will take place alongside more traditional and somber observances, including the laying of a wreath by President Barack Obama at the Tomb of the Unknown Soldier at Arlington National Cemetery, just across the Potomac River from the nation's capital.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Five development concept of innovation, harmonization, green, openness and sharing
吕特在周一晚间的辩论中重申,他不会与维尔德斯所属的政党组建联合政府,他甚至还表示不可能组建一个依赖这个反移民政党支持的政府。吕特表示:“我不会再次与这样的政党合作。”在2010年选举之后,吕特组建的首个少数派政府受到自由党的支持。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Mr Yao, 46, is based in the southern Chinese city of Shenzhen and first made his fortune in real estate. But it was his Baoneng Group’s foray into insurance and subsequent raid on Vanke, a cross-city property rival, that fuelled the estimated ninefold increase in his net worth in the space of a year.
2. How to write a CV
Swyft有50家短信应用合作伙伴,包括Kakao Talk, Facebook Messenger, BlackBerry Messenger和 Line。这种合作让这家只有11个人的小公司能接触到25亿注册用户。随着利用短信应用赚钱的办法不断演化,这家年轻的创业公司已探索出一条可让各大品牌挤进人们聊天领域的生财之道。(财富中文网)

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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据外媒体育网站sbnation.com报道,德国战车在刚刚结束的比赛中以四粒进球完胜葡萄牙。比赛结果令人震惊,多数观察员原本希望葡萄牙的攻势能更猛烈些。但这是否是本届世界杯又一场比分悬殊的比赛?的确不足为奇。

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